NS96 DISC REMOVER

Congenital hypothyroidism (CH) is an endocrine disorder of newborns characterized by the decreased levels of thyroid hormones: thyroxine (T4) and triiodothyronine (T3) in periferal blood. In early perinatal period manifestations of CH are often non-specific, subtle or even non-existent [1-2]. However, the disease, if undiagnosed and untreated, leads to severe

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the most common human enzyme deficiency; an estimated 400 million people worldwide are affected by this enzymopathy (6). With regards to the demographics of G6PD deficiency, most of the affected individuals reside in Africa, the Middle East, and Southeast Asia. The G6PD enzyme catalyzes an oxidation/reduction reaction.

Galactosemia is an inherited metabolic abnormality comprising three distinctive clinical entities of the galactose pathway defects. Classic galactosemia is due to -Dgalactose- 1-phosphate-uridyl-transferase (GALT) defect (1). The test principle is based on extraction of Galactose & Galactose-1-phosphate from dried blood spot followed by enzymatic conversion of Galactose-1-phosphate & Galactose. Two kinds of extraction methods (acidic and heat) can be used for extraction step.